Aluminum oxide crystals, aka Corundum or bauxite, is an inert material and therefore, can have no specific adverse reaction to it. Popular gemstones--the ruby and the sapphire--are common forms of aluminum oxide. The hardness of this material is second only to the diamond. There has been no conclusive evidence that suggests adverse complications have been discovered from inhaling aluminum oxide crystals. In fact, aluminum oxide has been used for many years as a dental abrasive and in joint replacements due to the hardness of the crystals and the hard edges. Safety precautions should be taken when it comes to inhaling any foreign substance, especially as related to the technician performing the procedure. The patient should wear a protective covering over the eyes as aluminum oxide crystals are significantly heavier than most particles and fall quickly towards the floor when airborne. Many microdermabrasion machines have made significant improvements to their machines to minimize the particulate matter before it escapes into the air, especially during disposal and refilling procedures. If there are still concerns, a few manufacturers are now designing machines that utilize alternative crystal substances as their abrasive ingredient.